The three large, prospective multi-site cohort studies, conducted in collaboration with Johns Hopkins University, are one of the largest, most comprehensive and rigorous evaluations ever undertaken in the field of AI-driven clinical decision support for using multi-modal data to improve patient outcomes.
These results, showing high provider adoption and associated mortality and morbidity reductions, are a milestone for the field of AI and are the culmination of nearly a decade of significant technological investment, deep collaboration, the development of novel techniques and, for the first time, rigorous evaluation.
earlier detection on the most severe sepsis cases
high sensitivity of sepsis case identification
frontline user adoption over 2+ years
relative reduction in sepsis mortality
Using data from 764,707 patient encounters (17,538 with sepsis) across five hospitals in both academic and community-based hospital settings with 2,000+ providers using the software, this research shows accurate early detection (1 in 3 cases were physician confirmed) at high sensitivity (82%) and significant lead time (5.7 hours earlier), high provider adoption (89%), and associated significant reductions in mortality, morbidity and length of stay.
Most significantly, the studies show timely use of Bayesian’s AI platform is associated with a relative reduction in mortality of 18.2%.
“Though the promise of sepsis-detection technologies has been brewing for years, these new studies were the first to quantitatively and qualitatively evaluate how the technology is adopted, used, and experienced, and its actual impact in a large population”
– STAT – 7/21/22 –
“This tool makes every clinician more efficient and can let you manage more patients because there’s less work to do,” said Lee Sacks, MD, founding CEO of Advocate Physician Partners. “So I think, going forward staff are going to choose to work in organizations that have a tool like this because it makes them more effective.”
– Becker’s Hospital Review – 8/11/22 –
“I think that this model for machine learning may prove as vital to sepsis care as the EKG [electrocardiogram] machine has proved in diagnosing a heart attack,” says Karin Molander, MD, chair of the nonprofit Sepsis Alliance.
– Scientific American – 8/01/22 –
Conducted over a five-year period at five hospitals in both the academic and community-based hospital settings and across every department (including the ED), the studies included data from 764,707 patient encounters (17,538 were septic). In the prospective deployments spanning 2.5 years, over 4,000 caregivers (2,000+ were providers) participated in the research, using Bayesian’s adaptive AI platform to help augment their care of patients and empower their decision and documentation processes.
While retrospective studies have demonstrated the theoretic capacity of AI/machine learning-based models to detect various conditions early, few studies have reported on clinical implementations of these models to effectively monitor, tune and learn over time to continually improve performance. Additionally, there haven’t been any studies that have associated adoption amongst thousands of providers using the tool across multiple sites and settings with actual reductions in mortality.
There has been a lot of research published focusing on CDS for sepsis detection, but most included far fewer patients and often only a single site or one or two units within the hospital. Nothing has approached the size of these studies. Likewise, the diversity of the settings where this platform was deployed (community and academic hospitals and all of their associated units) better represent real-world deployment and application.
This longitudinal approach, where we monitored patients beginning in the ED, through every transition and on to discharge, was key in achieving the reduction results in mortality. The scope of this research shows the relevancy of this approach no matter the setting, whether it be a standalone community hospital or a large academic medical center.